Weight Loss Medications: Simple Comparison

Overview of how semaglutide, tirzepatide, and phentermine work in simple terms.

1. Semaglutide

Type: Hormone-based (GLP-1 receptor agonist). Mimics natural fullness hormones. Helps you feel full faster, slows digestion, and reduces appetite.

2. Tirzepatide (Mounjaro)

Type: Hormone-based (dual GIP + GLP-1). Works like semaglutide but stronger by targeting two hormones. Helps increase fullness and improve blood sugar control.

3. Phentermine

Type: Stimulant (sympathomimetic). Works on the nervous system to reduce hunger and increase alertness. Acts more like a stimulant rather than a hormone.

Key Differences

MedicationTypeHow it Works
SemaglutideHormone-basedMimics fullness signals
TirzepatideHormone-based (dual)Stronger fullness + metabolism effects
PhentermineStimulantSuppresses appetite via brain stimulation